Curent staffs

	Head: Assoc. Prof. Dr. Trinh Hong Thai, Lecturer Education: PhD1996, VNU University of Science, Vietnam Postdoc: University of Montpellier II, Institute of Structural Biology Jean-Pierre Ebel, France (1996-1997, 1999-2000) Specification: Protein Biochemistry Tel:  (84) 24 3557 5495 Email: thaith@vnu.edu.vn
	Dr. To Thanh Thuy, Lecturer Education: PhD: 2006, Univeristy of Wuerzburg, Germany Postdoc: National University of Singapore, Singapore (2008-2012 ) Specification: Endocrinology, bone metabolism, Molecular biology Tel: 0988738016 (mobile)            Email: ttthuy2012@gmail.com
	Dr. Do Minh Ha, Lecturer Education: PhD 2011, Lomonosov Moscow State University, Russia. Specification: Biophysic, Bioorganic chemistry. Tel: 02438581264 (office), 0938692282 (mobile) Email: hadm@hus.edu.vn
	Dr. Nguyen Thi Tu Linh, Lecturer Education: PhD 2018, VNU University of Science Specification: Human Molecular Biology Tel: 0989382559 (mobile) Email: nguyenthitulinh@hus.edu.vn
	Dr. Bui Phuong Thao, Lecturer Education: PhD 2019, University of Liverpool, the UK Specification:  Proteomics, Structural Biology and Bioinformatics Tel: 0378095867 (mobile) Email: buiphuongthao@hus.edu.vn

Research Interests and activities                                                                   

Proteomics and Structural Biology Unit specializes in investigating proteins in human and other organism under the situation of normal, disease and stress, including:

• Proteomics in research of cancer and other diseases: leukemia, hepatocellular carcinoma, colorectal cancer, breast cancer and infectious diseases.
• Study of mitochondrial DNA alterations, enzymes, reactive oxygenous species, antioxydants in relation to human diseases.
• Structural Biology: Structure analysis, modelling, simulation and design of protein in drug development.
• Use medaka and zebrafish as models for studying physiological and pathological processes in human.

Selected research projects

• Proteomic analysis of plasma exosomal proteins in patients with non-small cell lung cancer, funded by Vietnam National University, Hanoi, code: KLEPT.18.03 (2018-2021). PI: Assoc. Prof.Dr. Trinh Hong Thai. 
• In silico screening of some natural compounds from Vietnamese plants capable of interacting with NLRP3 inflammasome and combine with biological methods for development of potential products for Gout treatment (2018-2020), funded by Vietnam National University, Hanoi, code: QG.18.11. PI. Dr. Do Minh Ha.
• Establish of osteoporosis disease model using transgenic medaka fish and assessment of in vivo anti-osteoporotic effects of some natural and synthetic compounds (2015-2018), funded by National Foundation for Science and Technology (Nafosted), code: 106-YS.06-2014.15. PI: Dr. To Thanh Thuy
• Investigation of matrix metalloproteinase and tissue inhibitor of metalloproteinase in colorectal cancer (2013-2015), funded by Vietnam National University, Hanoi, code: QGTD.13.06, PI: Assoc. Prof.Dr. Trinh Hong Thai. 
• Detection of mitochondrial DNA mutations in Vietnamese patients using molecular biological methods (2012-2015), funded by Ministry of Science and Technology, code: KC.04.10/11-15. PI: Assoc. Prof.Dr. Trinh Hong Thai.
• Analysis of differentially expressed proteins in human liver cancer patients (2009-2012)  funded by Vietnam National University, Hanoi,  code: KLEPT.09.02. PI: Assoc. Prof.Dr. Trinh Hong Thai.
• Plasma proteomic analysis of leukemia (2006-2008), funded by basic project in natural sciences, code: 609506, PI: Assoc. Prof.Dr. Trinh Hong Thai.

Selected Publications

• Pham Van Cuong, Pham Thi Thanh, Lai Thi Thuy, Trinh Cong Dat, Nguyen Vuong Minh Huong, Ha Thi Minh Tam, Phuong Thien Thuong, Tran Duc Long, Chistoph Winkler, To Thanh Thuy, 2020. Icariin reduces bone loss in a Rankl-induced transgenic medaka (Oryzias latipes) model for osteoporosis. J Fish Biol. 1–10. https://doi.org/ 10.1111/jfb.14241.
• Nguyen Thuy Quynh, Le Thi Thanh Nhan, Le Lan Phuong, Bui Phuong Thao, Nguyen Thi Tu Linh, Le Trung Tho, Trinh Hong Thai, 2020. Mitochondrial A10398G alteration in plasma exosome of non-small cell lung cancer patients. VNU Journal of Science: Medical and Pharmaceutical Sciences, Vol. 36, No. 4 (2020) 50-59. https://doi.org/10.25073/2588-1132/vnumps.4275.
• Thao Phuong Bui, Anh Ngoc Hoang, Phuong Lan Le, Bich Thi Pham, Linh Thi Tu Nguyen, Ha Minh Do, To Van Ta and Thai Hong Trinh, 2017. Matrix metalloprpoteinases in Vietnamese patients with colorectal cancer. Oncology letters, 13: 2097-2104.
• Trần Thị Thùy Trang, Phạm Văn Cường, Phạm Thị Thanh, Hà Thị Minh Tâm, Trần Đức Long, Tô Thanh Thúy (2017). Thời gian sốc nhiệt và mức độ tổn thương xương của ấu trùng cá medaka chuyển gen rankl: HSE: CFP dòng c1c8 làm mô hình bệnh loãng xương. Tạp chí Khoa học ĐHQGHN: Khoa học Tự nhiên và Công nghệ, Tập 33(2S): 248-255.
• Lê Lan Phương, Nguyễn Thị Nga, Trịnh Hồng Thái, (2017). Biến đổi -C160A trong vùng promoter của gen CDH1 ở bệnh nhân ung thư vú người Việt Nam. Tạp chí Khoa học ĐHQGHN: Khoa học TN&CN, 33(2S): 96-102.
• Jan Dimberg, Thai Trinh Hong, Linh Tu Thi Nguyen, Marita Skarstedt, Sture Lofgren and Andreas Matussek, 2015. Common 4977 bp deletion and novel alterations in mitopchondrial DNA in Vietnamese patients with breast cancer. Springer Plus, 4: 58.
• Hoàng Ngọc Anh, Nguyễn Văn Hoàn, Bùi Phương Thảo, Lê Lan Phương, Phạm Thị Bích, Nguyễn Thị Tú Linh, Đỗ Minh Hà, Trịnh Hồng Thái, 2015. Hoạt tính của proteinase kim loại (MMP-2 và MMP-9) ở bệnh nhân ung thư đại trực tràng. Tạp chí Sinh học, 37 (1se): 279-288.
• Nguyễn Thị Tú Linh, Nguyễn Bỉnh Hiếu, Đỗ Minh Hà, Tạ Văn Tờ, Trịnh Hồng Thái, 2015.  Phân tích biến đổi A10398G ty thể trên bệnh nhân ung thư vú ở Việt Nam. Tạp chí Khoa học, ĐHQGHN, 31 (2):36-43.
• Phạm Văn Cường, Phạm Thị Thanh, Nguyễn Thúy Hoa, Trần Đức Long, Tô Thanh Thúy, 2015. Tách dòng cá medaka chuyển gen rankl:HSE:CFP dùng làm mô hình nghiên cứu bệnh loãng xương. Tạp chí khoa học, ĐHQGHN 31 (4S): 24-34.
• Jan Dimberg, Thai Trinh Hong, Marita Skarstedt, Sture L Normal 0 false false false EN-US X-NONE X-NONEöfgren, Niklas Zar and Andreas Matussek, 2014. Novel and differential accumulation of mitochondrial DNA deletions in Swedish and Vietnamese colorectal cancer patients. Anticancer Research, 34: 147-152.